DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients
Identifieur interne : 000E34 ( Main/Exploration ); précédent : 000E33; suivant : 000E35DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients
Auteurs : Leen J M. Seys [Belgique] ; W. Widagdo [Pays-Bas] ; Fien M. Verhamme [Belgique] ; Alex Kleinjan [Pays-Bas] ; Wim Janssens [Belgique] ; Guy F. Joos [Belgique] ; Ken R. Bracke [Belgique] ; Bart L. Haagmans [Pays-Bas] ; Guy G. Brusselle [Belgique]Source :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Dipeptidyl peptidase 4, Récepteurs viraux.
- anatomopathologie : Broncho-pneumopathie chronique obstructive, Poumon.
- effets indésirables : Tabagisme.
- Adulte, Adulte d'âge moyen, Enquêtes et questionnaires, Femelle, Humains, Mâle, Régulation positive, Sujet âgé.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Dipeptidyl Peptidase 4, Receptors, Virus.
- adverse effects : Smoking.
- pathology : Lung, Pulmonary Disease, Chronic Obstructive.
- Adult, Aged, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Up-Regulation.
Abstract
The MERS coronavirus receptor, dipeptidyl peptidase 4 is upregulated in the lungs of smokers and chronic obstructive pulmonary disease (COPD) patients. This offers a potential mechanism for the increased susceptibility of smokers and COPD patients for MERS-CoV infection.
Url:
DOI: 10.1093/cid/cix741
PubMed: 29020176
PubMed Central: 7108100
Affiliations:
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Brusselle</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University HospitalGhent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University HospitalGhent</wicri:regionArea><wicri:noRegion>Ghent University HospitalGhent</wicri:noRegion></affiliation></author></analytic><series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Dipeptidyl Peptidase 4 (analysis)</term><term>Female</term><term>Humans</term><term>Lung (pathology)</term><term>Male</term><term>Middle Aged</term><term>Pulmonary Disease, Chronic Obstructive (pathology)</term><term>Receptors, Virus (analysis)</term><term>Smoking (adverse effects)</term><term>Surveys and Questionnaires</term><term>Up-Regulation</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Broncho-pneumopathie chronique obstructive (anatomopathologie)</term><term>Dipeptidyl peptidase 4 (analyse)</term><term>Enquêtes et questionnaires</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Poumon (anatomopathologie)</term><term>Récepteurs viraux (analyse)</term><term>Régulation positive</term><term>Sujet âgé</term><term>Tabagisme (effets indésirables)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Dipeptidyl Peptidase 4</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Dipeptidyl peptidase 4</term><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Broncho-pneumopathie chronique obstructive</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Tabagisme</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term><term>Pulmonary Disease, Chronic Obstructive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Surveys and Questionnaires</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enquêtes et questionnaires</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Régulation positive</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The MERS coronavirus receptor, dipeptidyl peptidase 4 is upregulated in the lungs of smokers and chronic obstructive pulmonary disease (COPD) patients. 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Seys</name></noRegion><name sortKey="Bracke, Ken R" sort="Bracke, Ken R" uniqKey="Bracke K" first="Ken R" last="Bracke">Ken R. Bracke</name><name sortKey="Brusselle, Guy G" sort="Brusselle, Guy G" uniqKey="Brusselle G" first="Guy G" last="Brusselle">Guy G. Brusselle</name><name sortKey="Janssens, Wim" sort="Janssens, Wim" uniqKey="Janssens W" first="Wim" last="Janssens">Wim Janssens</name><name sortKey="Joos, Guy F" sort="Joos, Guy F" uniqKey="Joos G" first="Guy F" last="Joos">Guy F. Joos</name><name sortKey="Seys, Leen J M" sort="Seys, Leen J M" uniqKey="Seys L" first="Leen J M" last="Seys">Leen J M. Seys</name><name sortKey="Verhamme, Fien M" sort="Verhamme, Fien M" uniqKey="Verhamme F" first="Fien M" last="Verhamme">Fien M. Verhamme</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Widagdo, W" sort="Widagdo, W" uniqKey="Widagdo W" first="W" last="Widagdo">W. Widagdo</name></region><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name><name sortKey="Kleinjan, Alex" sort="Kleinjan, Alex" uniqKey="Kleinjan A" first="Alex" last="Kleinjan">Alex Kleinjan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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